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GPC3抗体

Mouse Monoclonal GPC3 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
GPC3抗体
英文名称：
Mouse Monoclonal GPC3 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 518 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
GPC3

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesSGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2
Entrez GeneID2719
clone9C2
WB Predicted band size65.5kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenPurified recombinant fragment of human GPC3 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using GPC3 mouse mAb against HepG2 (1), HEK293 (2), Jurkat (3), SK-N-SH (4), PC-12 (5), F9 (6)and Mouse liver (7) cell lysate.    


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       Flow cytometric analysis of Jurkat cells using GPC3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of NIH/3T3 cells using GPC3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of C6 cells using GPC3 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using GPC3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using GPC3 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于GPC3抗体的参考文献概览(信息基于公开研究数据整理，具体文献请核实原文)：

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1. **文献名称**："A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin and glypican-3"

**作者**：Yamaguchi T, et al.

**摘要**：报道了一种靶向GPC3和间皮素的双特异性单域抗体(HN3)，通过阻断Wnt/YAP信号通路抑制肿瘤生长，并在肝癌小鼠模型中显示出显著抗肿瘤效果。

2. **文献名称**："ImmunoPET imaging of glypican-3 in hepatocellular carcinoma with 89Zr-labeled antibodies"

**作者**：Fernandez A, et al.

**摘要**：研究利用锆-89标记的GPC3抗体进行免疫PET成像，证明其在肝细胞癌小鼠模型中可高灵敏度检测肿瘤，为临床无创诊断提供了潜在工具。

3. **文献名称**："Chimeric antigen receptor T cells targeting glypican-3 suppress hepatocellular carcinoma growth"

**作者**：Gao H, et al.

**摘要**：开发了靶向GPC3的CAR-T细胞疗法，体外和体内实验显示其能特异性识别并杀伤GPC3阳性肝癌细胞，且在小鼠模型中显著抑制肿瘤进展。

4. **文献名称**："GPC3 antibody-drug conjugate exhibits potent antitumor activity against hepatocellular carcinoma"

**作者**：Li W, et al.

**摘要**：构建了GPC3抗体-药物偶联物(ADC)，通过靶向递送细胞毒性药物，在多种肝癌模型中有效诱导肿瘤细胞凋亡，并与索拉非尼联用增强疗效。

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建议通过PubMed或Web of Science检索具体文献以获取完整信息。

       

背景信息

The glypican-3 (GPC3) antibody targets GPC3. a cell surface heparan sulfate proteoglycan anchored to the plasma membrane. GPC3 is part of the glypican family, which regulates cellular signaling pathways (e.g., Wnt, Hedgehog, YAP) during embryonic development. While minimally expressed in healthy adult tissues, GPC3 is overexpressed in several cancers, particularly hepatocellular carcinoma (HCC), malignant melanoma, and ovarian cancer, making it a promising tumor biomarker and therapeutic target.

GPC3 antibodies have emerged as critical tools in cancer diagnostics and therapy. In diagnostics, they enable immunohistochemical detection of GPC3 in tumor biopsies or liquid biopsies, aiding HCC differentiation from benign liver conditions. Therapeutically, GPC3 antibodies are engineered into antibody-drug conjugates (ADCs), bispecific antibodies, or CAR-T cell therapies. For instance, codrituzumab (an anti-GPC3 monoclonal antibody) and YP7 (an ADC) have shown preclinical efficacy by delivering cytotoxic agents directly to GPC3-positive tumors. CAR-T cells targeting GPC3 have demonstrated antitumor activity in early-phase clinical trials for HCC.

Challenges include tumor heterogeneity in GPC3 expression and potential off-target effects. Ongoing research focuses on optimizing antibody affinity, developing combination therapies (e.g., with immune checkpoint inhibitors), and exploring novel formats like nanobodies to enhance tumor penetration. Overall, GPC3 antibodies represent a versatile platform for precision oncology, with continued advancements expected to improve cancer detection and treatment outcomes.

       
GPC3抗体;GPC3;GPC3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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