GAB1抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using GAB1 mouse mAb against HEK293 (1) cell lysate.    

  
  

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     Flow cytometric analysis of Jurkat cells using GAB1 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using GAB1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human kidney tissues using GAB1 mouse mAb with DAB staining.    

  
  

GAB1 (GRB2-associated binding protein 1) is a scaffolding/adaptor protein critical for signal transduction downstream of receptor tyrosine kinases (RTKs) and cytokine receptors. It belongs to the GAB/DOS family and contains multiple functional domains, including a pleckstrin homology (PH) domain that binds phosphatidylinositol lipids, and tyrosine phosphorylation sites that recruit signaling molecules like PI3K, SHP2. and CRKL. GAB1 facilitates the activation of key pathways such as PI3K/AKT and RAS/MAPK, regulating cell proliferation, survival, migration, and differentiation.

GAB1 antibodies are essential tools for studying its role in cellular signaling. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect GAB1 expression, phosphorylation status, and protein-protein interactions. These antibodies help researchers explore GAB1's involvement in physiological processes and diseases, particularly cancer, where GAB1 overexpression or dysregulation is linked to tumor progression and metastasis. For example, aberrant GAB1 signaling is associated with breast, lung, and liver cancers. Additionally, GAB1 antibodies may aid in understanding developmental disorders and immune responses, as GAB1 interacts with MET, EGFR, and other receptors implicated in tissue morphogenesis and inflammation. Their specificity and reliability make GAB1 antibodies valuable for both basic research and potential clinical applications in diagnostics or therapeutic monitoring.