HAS3抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Flow cytometric analysis of HeLa cells using HAS3 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using HAS3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human prostate tissues using HAS3 mouse mAb with DAB staining.    

  
  

The HAS3 (Hyaluronan Synthase 3) antibody is a tool used to study the enzyme responsible for synthesizing hyaluronan (HA), a key component of the extracellular matrix. HAS3. one of three mammalian HA synthase isoforms (HAS1. HAS2. HAS3), catalyzes the production of HA, a high-molecular-weight glycosaminoglycan involved in cell adhesion, migration, and tissue hydration. Unlike HAS1 and HAS2. HAS3 generates shorter HA chains and is often associated with dynamic cellular processes, including inflammation, cancer progression, and wound healing.

HAS3 expression is upregulated in various pathological conditions, such as tumorigenesis, where it promotes metastasis by enhancing cell motility and angiogenesis. It also plays roles in chronic inflammatory diseases and fibrotic disorders. Researchers use HAS3 antibodies to detect protein expression levels, localize the enzyme in tissues or cultured cells, and investigate its regulatory mechanisms in both normal physiology and disease.

Commercial HAS3 antibodies are typically developed in rabbit or mouse hosts, targeting specific epitopes in the enzyme's cytoplasmic or transmembrane domains. Validation methods include Western blotting, immunohistochemistry, and knockout controls. These reagents are critical for exploring HA-mediated pathways and therapeutic strategies targeting HA synthesis in conditions like cancer and fibrosis.