RAP1A抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Flow cytometric analysis of A431 cells using RAP1A mouse mAb (green) and negative control (red).    

  
  

**Background of RAP1A Antibody**

RAP1A (Ras-related protein 1A) is a small GTPase belonging to the RAS superfamily, involved in regulating diverse cellular processes, including cell adhesion, proliferation, differentiation, and intracellular signaling. It functions as a molecular switch, cycling between an active GTP-bound state and an inactive GDP-bound state. RAP1A interacts with effector proteins such as integrins, MAPK pathways, and regulators like GTPase-activating proteins (GAPs) or guanine nucleotide exchange factors (GEFs) to mediate signaling cascades. Dysregulation of RAP1A has been linked to cancers, immune disorders, and cardiovascular diseases.

RAP1A antibodies are essential tools for studying its expression, localization, and function in biological systems. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Specific RAP1A antibodies target distinct epitopes, enabling the detection of endogenous RAP1A isoforms and post-translational modifications. Validated antibodies help elucidate RAP1A’s role in pathways like cAMP signaling, cell-matrix interactions, and vesicle trafficking.

Due to its homology with other RAS family members (e.g., RAP1B), antibody specificity is critical to avoid cross-reactivity. Research utilizing RAP1A antibodies has advanced understanding of its dual roles as a tumor suppressor or promoter, depending on context, and its potential as a therapeutic target. Commercial RAP1A antibodies are often validated across species (human, mouse, rat) and cited in studies exploring cancer metastasis, platelet activation, and neurological processes.