PDX1抗体

The PDX1 antibody is a crucial tool in biomedical research, primarily used to detect Pancreatic and Duodenal Homeobox 1 (PDX1), a transcription factor essential for pancreatic development and β-cell function. PDX1. also known as IPF1. regulates insulin gene expression and is pivotal in pancreas organogenesis during embryogenesis. In adults, it maintains β-cell identity and glucose-responsive insulin secretion. Researchers employ PDX1 antibodies to study pancreatic development, diabetes mechanisms, and β-cell regeneration strategies. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and flow cytometry to localize and quantify PDX1 expression in tissues or cultured cells. PDX1’s role extends beyond diabetes; its dysregulation is linked to pancreatic cancer and congenital disorders. In stem cell research, PDX1 antibodies help assess differentiation efficiency toward insulin-producing cells. Commercial PDX1 antibodies are typically raised against conserved epitopes in human, mouse, or rat samples, with validation in knockout controls being critical for specificity. Recent advancements in single-cell genomics have renewed interest in PDX1 as a biomarker for β-cell subpopulations and disease progression.