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LRP5抗体

Mouse Monoclonal LRP5 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期:2025-05-10

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称:
LRP5抗体
英文名称:
Mouse Monoclonal LRP5 Antibody
品牌:
艾普蒂
产地:
武汉
保存条件:
Stored at -20°C for 488 year. Avoid repeated freeze / thaw cycles.
产品类别:
抗体
重组:
应用:
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性:
Human,Mouse,Rat
宿主:
Mouse
偶联物:
靶点:
LRP5

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesHBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; OPTA1; VBCH2
Entrez GeneID4041
clone2B11
WB Predicted band size179kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human LRP5 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


           

参考文献

以下是关于LRP5抗体的3篇模拟参考文献,涵盖不同研究方向:

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1. **文献名称**:*LRP5 Mutations in Human High Bone Mass Disorders and Osteoporosis*

**作者**:Gong Y. et al.

**摘要**:该研究探讨了LRP5基因突变对骨密度的影响,发现某些突变导致Wnt信号通路异常激活。研究中利用特异性LRP5抗体进行蛋白表达分析,证实了突变体在成骨细胞中的功能增强,为骨质疏松治疗提供了分子机制依据。

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2. **文献名称**:*LRP5 Antibody-Mediated Wnt Signaling Inhibition Suppresses Tumor Growth*

**作者**:Bafico A. et al.

**摘要**:通过开发靶向LRP5的单克隆抗体,研究者成功阻断了Wnt/β-catenin信号通路在癌细胞中的活性。实验显示,LRP5抗体可抑制肿瘤细胞增殖,表明其在癌症靶向治疗中的潜在应用价值。

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3. **文献名称**:*Role of LRP5 in Retinal Vascular Development: Insights from Antibody Blockade Experiments*

**作者**:Lu W. et al.

**摘要**:研究利用LRP5中和抗体探究其在视网膜血管生成中的作用。结果显示,抗体阻断LRP5后导致血管发育异常,提示LRP5在调控血管内皮细胞信号中的关键角色,为眼部疾病治疗提供新靶点。

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(注:以上文献为示例,实际引用需以真实发表论文为准。)

       

背景信息

**Background of LRP5 Antibodies**

LRP5 (low-density lipoprotein receptor-related protein 5) is a transmembrane receptor critical in the Wnt/β-catenin signaling pathway, regulating processes like bone development, metabolism, and cell proliferation. Mutations in *LRP5* are linked to skeletal disorders (e.g., osteoporosis-pseudoglioma syndrome) and diseases such as cancer, diabetes, and retinal angiogenesis. LRP5 antibodies are tools or therapeutic agents designed to modulate this pathway.

In research, anti-LRP5 antibodies help dissect Wnt signaling mechanisms, either by blocking ligand-receptor interactions (antagonists) or stabilizing them (agonists). Therapeutically, they are explored for treating bone disorders, cancers (e.g., colorectal, breast), and metabolic diseases. For instance, inhibiting LRP5 may suppress tumor growth by disrupting Wnt-driven proliferation. Conversely, activating LRP5 could enhance bone formation in osteoporosis.

Monoclonal antibodies targeting LRP5 are in preclinical development, with challenges including specificity and avoiding off-target effects in related receptors (e.g., LRP6). Their clinical potential hinges on balancing pathway modulation with safety. Overall, LRP5 antibodies represent a promising yet complex avenue for precision medicine in diverse diseases.

       
LRP5抗体;LRP5;LRP5 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ¥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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