YAP1抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using YAP1 mouse mAb against Hela (1), C6 (2) and Cos7 (3) cell lysate.    

  
  

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     Western blot analysis using YAP1 mouse mAb against mouse liver(1)PC-12 (2) NIH/3T3(3)NRK (4) C2C12(5)C6(6)F9(7) COS-7(8)MCF-7(9) cell lysate.    

  
  

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     Flow cytometric analysis of Hela cells using YAP1 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using YAP1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using YAP1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Mouse kidney，Rat kidney，Rabbit kidney using YAP1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Rat kidney using YAP1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Rabbit kidney using YAP1 mouse mAb with DAB staining.    

  
  

YAP1 (Yes-associated protein 1) is a transcriptional co-activator that plays a pivotal role in the Hippo signaling pathway, which regulates organ size, cell proliferation, apoptosis, and stem cell maintenance. It functions by shuttling between the cytoplasm and nucleus: when the Hippo pathway is active, YAP1 undergoes phosphorylation and cytoplasmic retention; when inactive, unphosphorylated YAP1 translocates to the nucleus, where it interacts with transcription factors (e.g., TEADs) to drive pro-growth and anti-apoptotic gene expression. Dysregulation of YAP1 is implicated in cancers, fibrosis, and developmental disorders due to its oncogenic potential and role in tissue regeneration.

YAP1 antibodies are essential tools for detecting YAP1 expression, localization, and activation status in research. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study Hippo pathway dynamics, cancer progression, and therapeutic targeting. Specific antibodies can distinguish between phosphorylated (inactive) and non-phosphorylated (active) YAP1 isoforms, aiding in mechanistic studies. Commercial YAP1 antibodies are often validated for cross-reactivity in human, mouse, and rat samples. Recent studies also explore YAP1's role in mechanotransduction, immune modulation, and regenerative medicine, further driving demand for reliable antibodies to dissect its multifaceted biological functions.