COTL1抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using COTL1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using COTL1 mouse mAb with DAB staining.    

  
  

The COTL1 (Coactosin-like protein 1) antibody is a research tool designed to detect and study the expression and function of the COTL1 protein, a member of the actin-binding ADF/cofilin family. COTL1 is implicated in regulating cytoskeletal dynamics, cellular motility, and inflammatory responses by interacting with actin filaments and modulating their polymerization. It is structurally characterized by a conserved coactosin-like domain and shares homology with coactosin, a protein originally identified in *Dictyostelium*.

COTL1 is highly expressed in immune cells, such as macrophages and neutrophils, where it participates in signaling pathways linked to leukotriene biosynthesis by stabilizing 5-lipoxygenase (5-LO), a key enzyme in inflammatory mediator production. Dysregulation of COTL1 has been associated with pathological conditions, including cancer metastasis, chronic inflammation, and autoimmune diseases. Studies suggest its role in promoting tumor cell invasion and migration via cytoskeletal remodeling, making it a potential biomarker or therapeutic target.

COTL1 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate protein localization, expression levels, and molecular interactions. Their applications span basic research in cell biology, immunology, and oncology, aiding in elucidating COTL1's mechanisms in health and disease. Validation of antibody specificity remains crucial, as cross-reactivity with homologous proteins may occur.