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BIRC5抗体

Mouse Monoclonal BIRC5 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
BIRC5抗体
英文名称：
Mouse Monoclonal BIRC5 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 465 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
BIRC5

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesAPI4; EPR-1
Entrez GeneID332
clone1H5
WB Predicted band size16kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human BIRC5 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of MSCS cells using BIRC5 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of Jurkat cells using BIRC5 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using BIRC5 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using BIRC5 mouse mAb with DAB staining.    


           

参考文献

以下是关于BIRC5抗体的3篇代表性文献摘要：

1. **《Survivin as a biomarker for cancer diagnosis and therapy》**

- 作者：Altieri, D.C.

- 摘要：研究BIRC5(生存素)在多种癌症中的异常表达，提出其作为诊断标志物的潜力，并探讨基于BIRC5抗体的免疫组化检测在肿瘤病理分析中的应用。

2. **《Structure and function of the survivin–antibody complex》**

- 作者：Ambrosini, G. 等

- 摘要：通过晶体学分析BIRC5蛋白与特异性抗体的结合位点，揭示抗体抑制BIRC5抗凋亡功能的分子机制，为靶向治疗提供结构基础。

3. **《Targeted delivery of anti-survivin antibody to tumors》**

- 作者：Li, F. 等

- 摘要：开发一种基于BIRC5抗体的纳米药物递送系统，实验显示其能选择性识别肿瘤细胞并诱导凋亡，显著抑制小鼠模型中实体瘤的生长。

4. **《Clinical significance of serum survivin antibody detection in cancer patients》**

- 作者：Kawasaki, H. 等

- 摘要：通过ELISA技术检测癌症患者血清中BIRC5抗体的水平，发现其与肿瘤分期和预后相关，提示其作为非侵入性预后评估工具的可行性。

       

背景信息

**Background of BIRC5 Antibody**

BIRC5 (Baculoviral IAP Repeat-Containing 5), also known as survivin, is a member of the inhibitor of apoptosis protein (IAP) family. It plays a dual role in regulating cell division and inhibiting programmed cell death (apoptosis). Structurally, BIRC5 contains a conserved baculovirus IAP repeat (BIR) domain critical for its anti-apoptotic function and interacts with microtubules during mitosis.

BIRC5 is highly expressed in embryonic tissues but is typically absent in most differentiated adult cells. However, its overexpression is strongly associated with numerous cancers, including breast, lung, colorectal, and pancreatic malignancies. This upregulation correlates with tumor progression, resistance to therapy, and poor prognosis, making BIRC5 a promising diagnostic and therapeutic target.

Antibodies targeting BIRC5 are widely used in research to detect its expression and localization in cells and tissues. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the study of BIRC5's role in cancer biology, drug resistance mechanisms, and cell cycle regulation. Additionally, BIRC5-specific antibodies are explored in therapeutic strategies, such as monoclonal antibody therapies or CAR-T cell engineering, to selectively target cancer cells.

Overall, BIRC5 antibodies serve as vital tools for understanding cancer pathogenesis and developing precision oncology approaches.

       
BIRC5抗体;BIRC5;BIRC5 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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