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NQO1抗体

Mouse Monoclonal NQO1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
NQO1抗体
英文名称：
Mouse Monoclonal NQO1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 458 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
NQO1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesDTD; QR1; DHQU; DIA4; NMOR1; NMORI
Entrez GeneID1728
clone4D12
WB Predicted band size31kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human NQO1 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using NQO1 mouse mAb against A549 (1), SKNES (2), HepG2 (3), MCF-7 (4) and Hela (5) cell lysate.    


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       Flow cytometric analysis of NIH/3T3 cells using NQO1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human testis tissues using NQO1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using NQO1 mouse mAb with DAB staining.    


           

参考文献

以下是3-4条关于NQO1抗体的参考文献示例(内容基于公开研究整理，非真实文献，仅供参考格式)：

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1. **"NQO1 Antibody Validation in Human Tumor Tissues: Implications for Prognostic Biomarker Studies"**

*Authors: Ross D., Siegel D.*

摘要：本研究验证了NQO1抗体在多种人类肿瘤组织中的特异性，发现其高表达与乳腺癌和肺癌患者的不良预后显著相关，提示NQO1可能作为癌症治疗靶点。

2. **"Comparative Analysis of NQO1 Antibody Specificity in Immunohistochemistry"**

*Authors: Traver R.D., et al.*

摘要：通过Western blot和免疫组化对比不同商业来源的NQO1抗体，发现部分抗体存在非特异性结合，强调了抗体选择对实验可靠性的重要性。

3. **"NQO1 Antibody-Based Detection of Enzyme Activity in Drug-Resistant Cancer Cells"**

*Authors: Siegel D., et al.*

摘要：利用NQO1单克隆抗体研究肿瘤细胞中NQO1酶活性，发现其过表达与化疗药物(如阿霉素)的耐药性相关，为克服耐药性提供新思路。

4. **"NQO1 C609T Polymorphism Detection by Antibody-Assisted Genotyping"**

*Authors: Asher G., et al.*

摘要：结合PCR和NQO1抗体分型技术，证明NQO1基因C609T多态性导致酶活性显著下降，为个体化癌症风险评估提供方法学支持。

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注：以上文献信息为示例性内容，实际引用时需通过PubMed、Web of Science等数据库检索真实文献并核对作者与摘要细节。

       

背景信息

The NAD(P)H:quinone oxidoreductase 1 (NQO1) antibody is a critical tool for studying the NQO1 enzyme, a cytosolic flavoprotein involved in cellular antioxidant defense and metabolic regulation. NQO1 catalyzes the two-electron reduction of quinones to hydroquinones, preventing redox cycling and oxidative stress. It requires FAD as a cofactor and functions as a homodimer. Research links NQO1 overexpression to various cancers (e.g., lung, breast, colorectal), where it may influence tumor progression, drug resistance, and apoptosis regulation. Conversely, the C609T polymorphism (rs1800566), which diminishes enzyme activity, is associated with increased cancer susceptibility.

NQO1 antibodies are widely used in biomedical research to detect protein expression and localization via techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence. Monoclonal antibodies offer high specificity for quantitative assays, while polyclonal antibodies may enhance sensitivity for detecting low-abundance targets. These reagents help elucidate NQO1's roles in redox homeostasis, chemoprotection, and disease mechanisms, including neurodegeneration (e.g., Alzheimer's, Parkinson's) and metabolic disorders. Commercial antibodies are typically validated against recombinant NQO1 or knockout cell lines to ensure reliability. As NQO1 gains attention as a therapeutic target or biomarker, its antibodies remain essential for diagnostic development and mechanistic studies.

       
NQO1抗体;NQO1;NQO1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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