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PRK2抗体新品

Mouse Monoclonal PRK2 Antibody

询价 20μl 起订

50μl 起订

100μl 起订

湖北更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

VIP1年

联系人：周经理

电话：027-19371278702拨打

手机：18008634902 拨打

邮箱：19384116026@163.com

产品详情:

中文名称：: PRK2抗体

英文名称：: Mouse Monoclonal PRK2 Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 433 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Mouse

偶联物：: 无

靶点：: PRK2

验证与应用

应用及物种

WB	1/500 - 1/2000	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/200 - 1/1000	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	1/200 - 1/400	Human,Mouse,Rat
Elisa	1/10000	Human,Mouse,Rat

产品详情

Aliases	PKN2; PAK2; PRK2; Pak-2; PRKCL2; PRO2042; MGC71074; MGC150606
Entrez GeneID	5586
clone	1D1
WB Predicted band size	140kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat,Monkey
Immunogen	Purified recombinant fragment of human PRK2 expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

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Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Western blot analysis using PRK2 mouse mAb against PC-12 (1), Cos7 (2), K562 (3), Jurkat (4), Hela (5), A431 (6), C6 (7), NIH/3T3 (8) and HEK293 (9) cell lysate.
Flow cytometric analysis of NIH/3T3 cells using PRK2 mouse mAb (blue) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human prostate tissues using PRK2 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using PRK2 mouse mAb with DAB staining.

参考文献

以下是关于PRK2(Protein Kinase C-related kinase 2)抗体的3篇参考文献的简要总结：

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1. **文献名称**: "PRK2/PKNγ regulates keratinocyte activation by suppressing EGFR signaling through phosphorylation of EGFR-T654"

**作者**: Takahashi H, et al.

**摘要**: 本研究利用PRK2特异性抗体(Western blot和免疫荧光)发现PRK2通过磷酸化EGFR-T654抑制其活性，调控角质形成细胞的增殖和分化，揭示了PRK2在皮肤屏障修复中的作用。

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2. **文献名称**: "PKN2/PRK2 promotes cell migration and tumor growth via the MEK-ERK pathway"

**作者**: Kim J, et al.

**摘要**: 通过PRK2抗体(免疫组化、siRNA实验)证明，PRK2在多种癌细胞中高表达，通过激活MEK-ERK信号通路促进肿瘤迁移和生长，提示其作为癌症治疗靶点的潜力。

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3. **文献名称**: "PRK2 interacts with Amyloid-β precursor protein and regulates its trafficking"

**作者**: Lee S, et al.

**摘要**: 使用PRK2抗体(免疫共沉淀)发现PRK2与β淀粉样前体蛋白(APP)结合，影响APP的胞内运输和Aβ生成，为阿尔茨海默病机制研究提供了新方向。

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提示：如需具体文献来源或更早年的研究，可进一步提供领域方向(如癌症、神经科学等)。

背景信息

**Background of PRK2 Antibody**

The PRK2 (protein kinase C-related kinase 2) antibody is a tool used to detect and study PRK2. a serine/threonine kinase belonging to the AGC family of protein kinases. PRK2. also known as PKN2 or Pkn2. shares structural homology with protein kinase C (PKC) and plays critical roles in diverse cellular processes, including cytoskeletal reorganization, cell migration, proliferation, and apoptosis. It is activated by Rho GTPases (e.g., RhoA, Rac1) and interacts with signaling pathways such as mTOR and PI3K/AKT, making it a key regulator of cellular responses to extracellular stimuli.

PRK2 antibodies are essential for investigating its expression, localization, and activation in various tissues and disease contexts. Dysregulation of PRK2 has been implicated in cancer, neurodegenerative disorders, and cardiovascular diseases. For instance, elevated PRK2 levels correlate with tumor progression and metastasis in certain cancers. Researchers utilize PRK2 antibodies in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore its functional mechanisms or diagnostic potential.

These antibodies are often validated for specificity against PRK2 isoforms or phosphorylated forms (e.g., Thr816/Thr822), ensuring accurate detection in experimental models. Their application aids in deciphering PRK2's role in health and disease, supporting drug discovery and biomarker development.

PRK2抗体;PRK2;PRK2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力，拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期	(2年)
注册资本	50万(元)
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	中间体,化学试剂