C-CBL抗体 新品

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     Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    

  
  

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     Western blot analysis using C-CBL mouse mAb against RAJI (1), RAW264.7 (2), K562 (3), SKBR-3 (4), 3T3-L1 (5), THP-1 (6) and PC-12 (7) cell lysate.    

  
  

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     Western blot analysis using C-CBL mouse mAb against PC-12(1)Raw264.7(2)NIH/3T3(3)NRK(4)C2C12(5)C6(6)F9(7)COS-7(8) cell lysate.    

  
  

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     Immunofluorescence analysis of Hela cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    

  
  

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     Immunofluorescence analysis of COS7 cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    

  
  

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     Immunofluorescence analysis of PC-12 cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    

  
  

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     Immunofluorescence analysis of NIH/3T3 cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    

  
  

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     Flow cytometric analysis of MCF-7 cells using C-CBL mouse mAb (blue) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using C-CBL mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using C-CBL mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Mouse kidney using C-CBL mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Rat kidney using C-CBL mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Rabbit kidney using C-CBL mouse mAb with DAB staining.    

  
  

C-CBL (Casitas B-lineage lymphoma) is a multifunctional adaptor protein and E3 ubiquitin ligase involved in regulating intracellular signaling pathways, particularly those linked to tyrosine kinase receptors. It plays a critical role in ubiquitination-mediated degradation of activated receptors and signaling molecules, thereby modulating cell proliferation, differentiation, and apoptosis. Dysregulation of C-CBL is implicated in various cancers and immune disorders due to mutations or altered expression levels that disrupt its tumor-suppressive or oncogenic functions, depending on cellular context.

C-CBL antibodies are essential tools for studying its expression, post-translational modifications, and interactions in both physiological and pathological settings. These antibodies enable detection of C-CBL in techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding research into its role in leukemia, solid tumors, and autoimmune diseases. Some studies highlight its dual nature—acting as a tumor suppressor by downregulating oncogenic signaling (e.g., in EGFR pathways) or promoting malignancy when mutated. Additionally, C-CBL antibodies help explore its involvement in immune cell regulation, such as T-cell receptor signaling. Research using these antibodies contributes to understanding disease mechanisms and potential therapeutic targeting of C-CBL-associated pathways.