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CD15抗体

Mouse Monoclonal CD15 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
CD15抗体
英文名称：
Mouse Monoclonal CD15 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 423 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CD15

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesLeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV
Entrez GeneID2526
clone4E10
WB Predicted band size59kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide of human CD15.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Immunofluorescence analysis of PC-2 cells using CD15 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunohistochemical analysis of paraffin-embedded human cerebellum tissues (left) and human liver cancer tissues (right) using CD15 mouse mAb with DAB staining.    


           

参考文献

以下是3篇与CD15抗体相关的代表性文献摘要(基于虚构内容示例，实际文献需通过数据库检索获取)：

1. **文献名称**: "CD15 expression in Hodgkin lymphoma: diagnostic utility and correlation with survival"

**作者**: Smith, A.B. et al.

**摘要**: 研究分析了CD15抗体在霍奇金淋巴瘤中的表达模式，证实其作为诊断标志物的敏感性，并发现CD15阳性与患者不良预后相关。

2. **文献名称**: "Comparative study of CD15 and CD30 in acute leukemia immunophenotyping"

**作者**: Jones, R.K. & Patel, L.

**摘要**: 通过流式细胞术比较CD15与CD30在急性髓系白血病(AML)中的表达，指出CD15在粒细胞分化中的特异性，支持其在白血病分型中的应用价值。

3. **文献名称**: "CD15 as a potential biomarker for tumor-associated macrophages in colorectal cancer"

**作者**: Chen, H. et al.

**摘要**: 探讨CD15在结直肠癌肿瘤微环境中的表达，发现其与肿瘤相关巨噬细胞(TAMs)浸润相关，提示CD15可能参与免疫抑制调控。

4. **文献名称**: "Optimization of CD15 immunohistochemistry in formalin-fixed tissues"

**作者**: Lee, S. et al.

**摘要**: 提出针对福尔马林固定组织的CD15抗体染色优化方案，解决了抗原修复中的技术难点，提升了染色特异性与一致性。

(注：以上为模拟内容，实际文献需通过PubMed、Google Scholar等平台以“CD15 antibody”、“CD15 biomarker”等关键词检索。)

       

背景信息

CD15 antibody targets the CD15 antigen, a carbohydrate epitope also known as Lewis X (LeX) or stage-specific embryonic antigen-1 (SSEA-1). Structurally, CD15 is a trisaccharide (Galβ1-4GlcNAcβ1-3Fuc) commonly expressed on glycolipids and glycoproteins. Initially identified as a differentiation marker in hematopoietic cells, it is predominantly found on granulocytes, monocytes, and certain B-cell subsets. CD15 also appears in epithelial cells and some tumors, making it a valuable biomarker in both research and diagnostics.

In normal physiology, CD15 mediates cell-cell adhesion and signaling, particularly during immune responses. It interacts with selectins on endothelial cells, facilitating leukocyte migration to inflammation sites. Pathologically, CD15 overexpression is linked to malignancies, including Hodgkin’s lymphoma, acute myeloid leukemia (AML), and adenocarcinomas. Its presence on Reed-Sternberg cells aids in diagnosing classical Hodgkin’s lymphoma, while loss of CD15 in colorectal cancer correlates with poor prognosis.

CD15 antibodies are widely used in immunohistochemistry to distinguish granulocytic lineages, monitor myeloid differentiation, and identify specific tumor subtypes. Therapeutic applications are emerging, with CD15-targeted therapies explored in cancers and inflammatory diseases. However, challenges remain due to CD15’s heterogeneous expression and structural variability across tissues. Recent studies also highlight its role in stem cell biology and microbial interactions, broadening its biomedical relevance. Ongoing research aims to refine its diagnostic utility and exploit its therapeutic potential.

       
CD15抗体;CD15;CD15 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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