RBP4抗体

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     Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    

  
  

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     Immunofluorescence analysis of HepG2 cells using RBP4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    

  
  

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     Flow cytometric analysis of HepG2 cells using RBP4 mouse mAb (green) and negative control (purple).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human liver cancer tissues (left) and stomach cancer tissues (right) using RBP4 mouse mAb with DAB staining.    

  
  

Retinol-binding protein 4 (RBP4), a 21-22 kDa secreted protein primarily produced by the liver and adipose tissue, functions as the main carrier of retinol (vitamin A) in the bloodstream. It transports retinol from hepatic stores to peripheral tissues, where it is converted to retinaldehyde and retinoic acid, essential for vision, immune function, and cellular differentiation. Dysregulated RBP4 levels have been linked to metabolic disorders, including insulin resistance, type 2 diabetes, obesity, and cardiovascular diseases, positioning it as a potential biomarker for metabolic syndrome.

RBP4 antibodies are critical tools for detecting and quantifying RBP4 in research and clinical diagnostics. They are widely used in techniques like ELISA, Western blotting, and immunohistochemistry to study RBP4 expression patterns in tissues or biological fluids. Commercially available antibodies are often raised against conserved epitopes, enabling cross-reactivity in humans, mice, and rats. Recent studies also explore RBP4's role in cancer progression (e.g., hepatocellular carcinoma) and ocular diseases (e.g., age-related macular degeneration), expanding its therapeutic and diagnostic relevance. However, assay variability due to RBP4's complex interactions with transthyretin and retinol requires careful antibody validation to ensure specificity in different experimental contexts.