MSI1抗体

The MSI1 antibody targets the Musashi-1 (MSI1) protein, an RNA-binding protein critical for post-transcriptional gene regulation. MSI1 is primarily expressed in neural stem/progenitor cells, where it maintains stem cell self-renewal by repressing translation of target mRNAs, including tumor suppressors like NUMB. It is also implicated in cancer biology, particularly in glioblastoma, medulloblastoma, and colorectal cancer, where its overexpression correlates with tumor aggressiveness, stem-like properties, and poor prognosis. MSI1 serves as a marker for cancer stem cells, contributing to therapy resistance and recurrence. Antibodies against MSI1 are widely used in research to study its expression and function via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These tools help elucidate MSI1's role in both normal development and oncogenesis, with potential diagnostic or therapeutic applications.