SNAI1抗体

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     Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    

  
  

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     Western blot analysis using SNAI1 mouse mAb against NTERA-2 cell lysate.    

  
  

The SNAI1 antibody is a crucial tool in studying the Snail family transcriptional repressor 1 (Snail1), encoded by the *SNAI1* gene. Snail1. a zinc-finger transcription factor, plays pivotal roles in embryonic development and cancer progression by regulating epithelial-mesenchymal transition (EMT). During EMT, epithelial cells lose adhesion and gain migratory properties, a process essential for gastrulation, neural crest formation, and wound healing. Dysregulation of Snail1 is implicated in tumor metastasis, as it promotes invasiveness, stem-like properties, and resistance to apoptosis and chemotherapy in cancer cells.

SNAI1 antibodies are widely used to detect Snail1 protein expression and localization in research models, including cell lines, tissues, and xenografts. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess Snail1’s role in EMT-related pathways and its correlation with clinical outcomes. These antibodies are critical for understanding Snail1’s interaction with signaling pathways (e.g., TGF-β, Wnt) and its suppression of E-cadherin, a key epithelial marker. Validated antibodies often target conserved regions, such as the N-terminal SNAG domain or C-terminal zinc fingers, and specificity is confirmed via knockout controls. Their applications span cancer biology, developmental studies, and therapeutic targeting of EMT in metastatic diseases.