STK11抗体

The STK11 (serine/threonine kinase 11) antibody is a critical tool for studying the STK11 gene and its encoded protein, also known as liver kinase B1 (LKB1). STK11 functions as a tumor suppressor, regulating cell metabolism, polarity, proliferation, and apoptosis through pathways like AMPK/mTOR signaling. Germline mutations in STK11 cause Peutz-Jeghers syndrome, a hereditary disorder linked to gastrointestinal polyps and increased cancer risk, while somatic mutations are implicated in sporadic cancers such as melanoma, lung, and cervical cancers. Antibodies targeting STK11 are widely used in research to detect protein expression, localization, and functional alterations via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help investigate STK11's role in cancer progression, metabolic regulation, and response to therapies. Commercial STK11 antibodies are typically raised in rabbits or mice, with specificity validated using knockout controls. Clones like D60C5 (Cell Signaling Technology) are commonly cited. Researchers rely on these reagents to explore STK11's interactions with binding partners (e.g., STRAD, MO25) and its impact on cellular energy sensing, making it vital for oncology, molecular biology, and translational studies.