FOXD3抗体

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     Western blot analysis using FOXD3 mouse mAb against NTERA-1 (1)?HUVE-12 (2), HEK293 (3), Hela (4), Jurkat (5), NIH/3T3 (6), K562 (7), RAW264.7 (8) and COS7 (9) cell lysate.    

  
  

FOXD3 (Forkhead box protein D3) is a transcription factor belonging to the Forkhead family, characterized by a conserved winged-helix DNA-binding domain. It plays critical roles in embryonic development, particularly in regulating neural crest cell differentiation, migration, and pluripotency maintenance in embryonic stem cells. FOXD3 suppresses or activates target genes by binding to specific DNA sequences, influencing cell fate decisions, lineage specification, and early developmental processes.

FOXD3 antibodies are essential tools for detecting and studying the expression, localization, and function of the FOXD3 protein in various biological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). These antibodies aid in exploring FOXD3's involvement in stem cell biology, cancer (e.g., as a tumor suppressor or metastasis promoter in certain cancers), and developmental disorders.

Research has linked FOXD3 dysregulation to diseases such as melanoma, neuroblastoma, and autoimmune conditions. Validated FOXD3 antibodies are crucial for ensuring specificity, as cross-reactivity with other Forkhead family members can occur. Their applications span basic research, diagnostics, and therapeutic target validation, underscoring their importance in understanding cellular differentiation and disease mechanisms.