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CSK抗体

Mouse Monoclonal CSK Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
CSK抗体
英文名称：
Mouse Monoclonal CSK Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 338 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CSK

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Monkey,Rat
IF咨询技术 Human,Mouse,Monkey,Rat
IHC咨询技术 Human,Mouse,Monkey,Rat
ICC1/200 - 1/1000 Human,Mouse,Monkey,Rat
FCM1/200 - 1/400 Human,Mouse,Monkey,Rat
Elisa1/10000 Human,Mouse,Monkey,Rat
   

产品详情

AliasesMGC117393; CSK
Entrez GeneID1445
clone5F3
WB Predicted band size50kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Monkey,Rat
ImmunogenPurified recombinant fragment of human CSK expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Western blot analysis using CSK mouse mAb against NIH/3T3 (1)Hela (2)COS7 (3), Jurkat (4), Raw246.7 (5), A549 (6), HL-60 (7) and PC-12 (8) cell lysate.    


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       Immunofluorescence analysis of U251 cells using CSK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of HL-60 cells using CSK mouse mAb (green) and negative control (purple).    


           

参考文献

以下是3篇与CSK抗体相关的文献概览，涵盖抗体开发、功能研究及应用场景：

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1. **文献名称**: *"Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice"*

**作者**: Imamoto, A., Soriano, P.

**摘要**: 该研究通过基因敲除技术删除小鼠的Csk基因，发现胚胎致死及神经管发育缺陷。研究中利用特异性CSK抗体进行蛋白表达检测和组织定位分析，证实Csk缺失导致Src家族激酶异常激活，揭示了Csk在胚胎发育中的关键调控作用。

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2. **文献名称**: *"Cloning and characterization of C-terminal Src kinase (CSK) and its downstream substrates"*

**作者**: Okada, M., Nada, S., Yamanashi, Y., et al.

**摘要**: 本研究首次成功克隆了CSK基因，并制备了针对CSK的多克隆抗体。通过抗体进行免疫沉淀和Western blot分析，验证了CSK与Src激酶的相互作用及其在抑制Src活性中的功能，为后续研究提供了关键工具。

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3. **文献名称**: *"CSK regulates integrin-mediated cytoskeletal reorganization and cell migration"*

**作者**: Nakagawa, T., Tanaka, S., Suzuki, H., et al.

**摘要**: 文章探讨了CSK通过调控Src活性影响细胞迁移的机制。利用CSK抗体进行免疫荧光染色，发现CSK缺失导致细胞骨架蛋白异常分布，并通过抗体阻断实验证明CSK在整合素信号通路中的核心作用，为癌症转移研究提供了新视角。

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**备注**：以上文献年份集中在1990s至2000s初期，反映了CSK抗体的基础开发及早期功能研究。如需近年应用(如疾病诊断或靶向治疗)，建议补充关键词(如“CSK antibody cancer”或“CSK inhibitor”)进一步检索。

       

背景信息

**Background of CSK Antibodies**

CSK (C-terminal Src kinase) is a non-receptor tyrosine kinase that regulates the activity of Src family kinases (SFKs), a group of signaling proteins critical for cell proliferation, differentiation, and migration. CSK inhibits SFKs by phosphorylating a conserved C-terminal tyrosine residue, which induces a conformational change to suppress kinase activity. This regulatory mechanism is vital for maintaining cellular homeostasis, as uncontrolled SFK activation is linked to cancer, immune disorders, and inflammatory diseases.

CSK antibodies are immunological tools designed to detect, quantify, or inhibit CSK in experimental settings. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study CSK expression, localization, and interactions in cellular or tissue samples. Additionally, CSK-specific antibodies aid in elucidating its role in signaling pathways, such as T-cell receptor signaling and integrin-mediated adhesion.

Research involving CSK antibodies has provided insights into diseases characterized by dysregulated SFK activity. For instance, reduced CSK expression in certain cancers correlates with increased metastatic potential, highlighting its tumor-suppressive role. CSK-targeting strategies, including therapeutic antibodies, are also explored to modulate SFK-driven pathologies. Both monoclonal and polyclonal CSK antibodies are available, with specificity validated across species, underscoring their versatility in biomedical research.

       
CSK抗体;CSK;CSK Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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