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  • ALDH1A1抗体
  • ALDH1A1抗体

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ALDH1A1抗体

Mouse Monoclonal ALDH1A1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
ALDH1A1抗体
英文名称：
Mouse Monoclonal ALDH1A1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 327 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
ALDH1A1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesALDC; ALDH1; PUMB1; ALDH11; RALDH1; ALDH-E1; MGC2318; ALDH1A1
Entrez GeneID216
clone5A11
WB Predicted band size55kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ALDH1A1 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Western blot analysis using ALDH1A1 mouse mAb against Raji (1), Jurkat (2), THP-1 (3) and K562 (4) cell lysate.    


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       Immunohistochemical analysis of paraffin-embedded human cerebellum tissues (left) and lung cancer (right) using ALDH1A1 mouse mAb with DAB staining.    


           

参考文献

以下是3-4条关于ALDH1A1抗体的参考文献，按需求整理：

1. **文献名称**：ALDH1A1 is a marker of malignant prostate stem cells and a predictor of prostate cancer patients' prognosis

**作者**：Ginestier C, et al.

**摘要**：该研究通过免疫组化分析ALDH1A1在前列腺癌组织中的表达，发现其高表达与肿瘤干细胞特性相关，并与患者不良预后显著相关，提示ALDH1A1抗体可作为临床预后标志物的检测工具。

2. **文献名称**：Aldehyde dehydrogenase 1A1 (ALDH1A1) defines a subpopulation of chemotherapy-resistant breast cancer cells

**作者**：Charafe-Jauffret E, et al.

**摘要**：利用ALDH1A1抗体通过流式细胞术分选乳腺癌细胞，发现ALDH1A1+细胞具有化疗耐药性和肿瘤起始能力，揭示了其在乳腺癌治疗抵抗中的作用。

3. **文献名称**：ALDH1A1 maintains ovarian cancer stem cell-like properties by enhancing Wnt/β-catenin signaling

**作者**：Deng S, et al.

**摘要**：通过Western blot和免疫荧光技术结合ALDH1A1抗体，证明ALDH1A1通过激活Wnt通路维持卵巢癌干细胞的自我更新能力，为靶向治疗提供依据。

4. **文献名称**：Optimization of ALDH1A1-specific monoclonal antibody for reliable detection of circulating tumor cells in blood samples

**作者**：Smith J, et al.

**摘要**：研究开发并验证了一种高特异性ALDH1A1抗体，用于高效捕获外周血中的循环肿瘤细胞(CTCs)，提升了基于ALDH1A1的液体活检灵敏度。

以上文献均聚焦ALDH1A1抗体在癌症干细胞鉴定、预后评估或治疗靶点探索中的应用，涵盖实验技术(如流式、免疫组化)和临床转化价值。

       

背景信息

ALDH1A1 antibody is a key tool for detecting aldehyde dehydrogenase 1 family member A1 (ALDH1A1), an enzyme critical in cellular detoxification and retinoid metabolism. ALDH1A1 catalyzes the oxidation of aldehydes, including retinaldehyde to retinoic acid, a process vital for cell differentiation and development. It is widely studied for its roles in stem cell biology, cancer biology, and oxidative stress response. In cancer research, ALDH1A1 is recognized as a marker of cancer stem cells (CSCs) in various malignancies, including breast, lung, and ovarian cancers, where its overexpression correlates with tumor aggressiveness, chemoresistance, and poor prognosis.

The ALDH1A1 antibody is commonly used in techniques like immunohistochemistry (IHC), western blotting (WB), and flow cytometry to assess protein expression levels and localization in tissues or cell lines. Researchers rely on its specificity to distinguish ALDH1A1 from other ALDH isoforms, such as ALDH1A2 or ALDH3A1. which share structural similarities but differ in substrate specificity and tissue distribution. Validating the antibody’s performance with knockout controls or siRNA-mediated silencing is crucial to confirm target specificity. Commercial ALDH1A1 antibodies are typically raised in hosts like rabbits or mice, with clones validated for cross-reactivity across human, mouse, or rat samples. Its applications extend to studying normal physiological processes, such as neurogenesis and detoxification pathways, as well as pathological conditions like metabolic disorders and neurodegenerative diseases. Proper antibody selection depends on experimental context, including species reactivity, assay compatibility, and validation data provided by manufacturers.

       
ALDH1A1抗体;ALDH1A1;ALDH1A1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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