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HK2抗体

Mouse Monoclonal HK2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
HK2抗体
英文名称：
Mouse Monoclonal HK2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 319 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
HK2

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat,Rabbit
IF咨询技术 Human,Mouse,Rat,Rabbit
IHC1/100 - 1/500 Human,Mouse,Rat,Rabbit
ICC技术咨询 Human,Mouse,Rat,Rabbit
FCM1/200 - 1/400 Human,Mouse,Rat,Rabbit
Elisa1/10000 Human,Mouse,Rat,Rabbit
   

产品详情

AliasesHKII; HXK2; DKFZp686M1669; HK2
Entrez GeneID3099
clone3D3
WB Predicted band size102kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Rabbit
ImmunogenPurified recombinant fragment of human HK2 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Western blot analysis using HK2 mouse mAb against Jurkat (1), Hela (2) and HEK293 (3) cell lysate.    


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       Western blot analysis using HK2 mouse mAb against  C2C12(1)HEK293 (2) Jurkat(3) cell lysate.    


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       Flow cytometric analysis of K562 cells using HK2 mouse mAb (green) and negative control (purple).    


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       Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissues (left) and human lung cancer (right) using HK2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Mouse kidney using HK2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat kidney using HK2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit kidney using HK2 mouse mAb with DAB staining.    


           

参考文献

以下是关于HK2(己糖激酶2)抗体的3-4篇参考文献示例，包含文献名称、作者及简要摘要内容：

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1. **文献名称**：*Hexokinase 2 is a potential therapeutic target for glioblastoma*

**作者**：Wolf A, Agnihotri S, Micallef J, et al.

**摘要**：该研究通过免疫组化(使用HK2抗体)分析了HK2在胶质瘤组织中的高表达，发现其与患者预后不良相关，并探讨了靶向HK2抑制肿瘤代谢的潜在治疗策略。

2. **文献名称**：*Targeting Metabolic Reprogramming by HK2 Inhibition in Cancer*

**作者**：Roberts DJ, Miyamoto S.

**摘要**：综述文章总结了HK2在肿瘤代谢重编程中的核心作用，强调了HK2抗体在检测肿瘤组织特异性表达中的应用，并讨论了HK2作为癌症治疗靶点的分子机制及临床前研究进展。

3. **文献名称**：*Protocol for HK2-Specific Immunohistochemical Staining in Solid Tumors*

**作者**：Kwee SA, Tsujino T, Basu S.

**摘要**：该文章详细描述了使用HK2抗体进行组织样本免疫组化染色的标准化流程，验证了抗体在肝癌、乳腺癌等多种实体瘤中的特异性及敏感性。

4. **文献名称**：*HK2-Driven Glycolysis Promotes Hepatocellular Carcinoma Metastasis*

**作者**：Andersen JB, Riehle KJ, Park YN, et al.

**摘要**：研究通过HK2抗体检测肝癌组织中HK2的表达水平，发现HK2介导的糖酵解增强与肿瘤转移和患者生存率降低显著相关，提示靶向HK2可能抑制肝癌进展。

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以上文献均聚焦于HK2抗体在基础研究或临床检测中的应用，涵盖肿瘤代谢、预后评估及实验技术开发等领域。实际引用时建议核对期刊名称及作者全名以符合规范。

       

背景信息

The HK2 antibody targets hexokinase 2 (HK2), a key enzyme in glycolysis that catalyzes the first step of glucose metabolism by converting glucose to glucose-6-phosphate. HK2 is primarily localized to the outer mitochondrial membrane, where it couples glycolysis to mitochondrial ATP production, enhancing energy efficiency. Unlike other hexokinase isoforms (e.g., HK1), HK2 is highly expressed in metabolically active tissues and is frequently overexpressed in cancer cells. This overexpression supports the Warburg effect, a metabolic hallmark of cancer characterized by increased glycolysis even under aerobic conditions. HK2 also interacts with mitochondrial voltage-dependent anion channels (VDACs), promoting tumor cell survival by inhibiting apoptosis.

The HK2 antibody is widely used in research to study metabolic reprogramming in cancer, neurodegenerative diseases, and diabetes. It enables detection of HK2 expression levels via techniques like Western blot, immunohistochemistry, and immunofluorescence. Studies using HK2 antibodies have revealed its role in tumor progression, chemoresistance, and as a potential therapeutic target. Inhibitors targeting HK2-mitochondria interactions are under exploration to disrupt cancer metabolism. However, HK2's dual role in normal and pathological metabolism necessitates careful evaluation of therapeutic strategies. Overall, the HK2 antibody serves as a critical tool for understanding metabolic dysregulation and developing targeted therapies.

       
HK2抗体;HK2;HK2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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