KLF4抗体

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     Immunohistochemical analysis of paraffin-embedded human lung cancer tissues (left) and human rectum tissues (right) using KLF4 mouse mAb with DAB staining.    

  
  

The Krüppel-like factor 4 (KLF4) antibody is a key tool for studying the KLF4 protein, a transcription factor belonging to the Krüppel-like family of zinc finger proteins. KLF4 regulates diverse cellular processes, including cell cycle progression, pluripotency, differentiation, and somatic cell reprogramming. It is highly expressed in embryonic stem cells and plays a critical role in maintaining pluripotency alongside OCT4. SOX2. and c-MYC. KLF4 also exhibits context-dependent roles in cancer, acting as either a tumor suppressor or oncogene depending on tissue type and cellular environment.

KLF4 antibodies are widely used in research to detect and quantify KLF4 expression in various applications, such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. These antibodies help investigate KLF4's involvement in development, tissue homeostasis, and disease mechanisms. Specific monoclonal or polyclonal antibodies are validated for target specificity, often using knockout cell lines or siRNA-mediated knockdown controls. Researchers rely on KLF4 antibodies to explore its regulatory networks in stem cell biology, cancer progression, and cellular reprogramming, making them essential for advancing studies in regenerative medicine and oncology. Quality validation, including cross-reactivity checks and functional assays, ensures reliable experimental outcomes.