HAS1抗体

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     Immunofluorescence analysis of U251 cells using HAS1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.    

  
  

The hyaluronan synthase 1 (HAS1) antibody targets the HAS1 enzyme, a member of the hyaluronan synthase family responsible for synthesizing hyaluronic acid (HA), a critical component of the extracellular matrix. HA plays vital roles in tissue hydration, cell signaling, and wound healing. HAS1. encoded by the *HAS1* gene, is a transmembrane protein that polymerizes HA by alternately adding UDP-glucuronic acid and UDP-N-acetylglucosamine. Unlike HAS2 and HAS3. HAS1 exhibits lower enzymatic activity and is often expressed under specific conditions, such as inflammation or tissue injury.

Research on HAS1 antibodies focuses on understanding its regulation and pathological roles. Dysregulated HAS1 expression is linked to diseases like cancer, fibrosis, and chronic inflammatory disorders. In cancers, HAS1 overexpression may promote tumor progression by enhancing HA-rich microenvironments that support metastasis and immune evasion. HAS1 antibodies are utilized in assays (e.g., Western blot, immunohistochemistry) to detect protein expression levels, study HA synthesis pathways, and evaluate therapeutic interventions targeting HA metabolism. Their specificity is critical for distinguishing HAS1 from other isoforms. Recent studies also explore HAS1 as a potential biomarker or therapeutic target, particularly in conditions driven by abnormal HA accumulation. However, challenges remain in elucidating its precise mechanisms and interactions within complex HA networks.