Rab10抗体

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     Western blot analysis using Rab10 mouse mAb against Hela (1) and NIH/3T3 (2) cell lysate.    

  
  

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     Immunofluorescence analysis of LOVO cells using Rab10 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.    

  
  

Rab10 antibody is a key tool for studying the Rab10 protein, a member of the Rab GTPase family involved in regulating intracellular vesicle trafficking and membrane dynamics. Rab10 plays critical roles in maintaining cellular homeostasis, including mediating exocytosis, endosomal recycling, and autophagy. It is particularly significant in neuronal cells, where it contributes to axon outgrowth, synaptic vesicle transport, and maintaining neuronal polarity. Dysregulation of Rab10 has been linked to neurological disorders (e.g., Alzheimer’s disease, Parkinson’s disease), metabolic conditions (e.g., diabetes), and cancer, highlighting its broad physiological relevance.

Rab10 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect expression levels, subcellular localization, and protein interactions. Researchers rely on these antibodies to explore Rab10’s role in cellular processes, such as its interaction with effector proteins or its activation state via GTP/GDP binding. Specific antibody clones (e.g., monoclonal vs. polyclonal) and host species (e.g., rabbit, mouse) offer flexibility for experimental designs. Validation methods, including knockout cell lines or siRNA knockdown, ensure antibody specificity. Given Rab10’s emerging importance in membrane trafficking pathways and disease mechanisms, its antibodies remain essential for advancing research in cell biology and therapeutic development.