ANK3抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04684(ANK3 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

ANK3 (Ankyrin-3), also known as Ankyrin-G, is a member of the ankyrin family of proteins that play critical roles in linking the spectrin-based cytoskeleton to integral membrane proteins in various cell types. It is predominantly expressed in neurons, cardiomyocytes, and epithelial cells, where it stabilizes specialized membrane domains, such as axon initial segments (AIS) and nodes of Ranvier in neurons, ensuring proper ion channel clustering and electrical signaling. ANK3 antibodies are immunological tools used to detect and study the expression, localization, and function of ANK3 in both physiological and pathological contexts.

Research involving ANK3 antibodies has highlighted the protein's importance in neurodevelopment, synaptic plasticity, and cardiac excitability. Mutations or dysregulation of ANK3 are associated with neuropsychiatric disorders (e.g., bipolar disorder, autism spectrum disorders) and cardiac arrhythmias (e.g., Brugada syndrome). These antibodies are widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ANK3's role in disease models, cellular organization, and molecular interactions. Additionally, ANK3 antibodies contribute to elucidating mechanisms underlying ankyrinopathies and evaluating potential therapeutic targets. Their specificity and validation are crucial for ensuring accurate experimental outcomes in studies of cell polarity, membrane stability, and intracellular signaling pathways.