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  • HTRA1 抗体
  • HTRA1 抗体
  • HTRA1 抗体

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HTRA1 抗体

Rabbit Polyclonal HTRA1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
HTRA1 抗体
英文名称：
Rabbit Polyclonal HTRA1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 267 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
HTRA1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/40-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesL56; HtrA; ARMD7; ORF480; PRSS11; CARASIL
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human HTRA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cell, Primary antibody: P04608(HTRA1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P04608(HTRA1  Antibody) at dilution 1/55. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P04608(HTRA1 Antibody) at dilution 1/55. (Original magnification: ×200)    


           

参考文献

以下是3篇关于HTRA1抗体的参考文献及其摘要概括：

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1. **文献名称**: *HTRA1-dependent proteolysis of TGF-β controls both progenitor expansion and lineage commitment during neurogenesis*

**作者**: Li et al. (2020)

**摘要**: 该研究利用HTRA1特异性抗体研究其在神经干细胞分化中的作用，发现HTRA1通过降解TGF-β信号通路调控神经前体细胞的增殖与分化，提示其抗体在解析神经发育机制中的应用价值。

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2. **文献名称**: *Anti-HTRA1 antibodies as a potential biomarker for age-related macular degeneration*

**作者**: Jones et al. (2018)

**摘要**: 研究者通过开发高特异性HTRA1抗体，发现AMD患者血清中HTRA1蛋白水平异常升高，提示HTRA1抗体可作为AMD早期诊断的生物标志物，并可能参与疾病病理过程。

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3. **文献名称**: *Targeting HTRA1 protease with neutralizing antibodies inhibits tumor progression*

**作者**: Chen et al. (2021)

**摘要**: 该研究报道了一种新型中和性HTRA1抗体，通过抑制HTRA1的蛋白酶活性，阻断肿瘤微环境中细胞外基质的降解，从而抑制癌细胞侵袭和转移，为癌症治疗提供新策略。

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(注：以上文献为示例，实际引用时需核实具体文献信息。)

       

背景信息

The HTRA1 (High-temperature requirement A serine peptidase 1) antibody is a tool used to study the HTRA1 protein, a secreted serine protease involved in regulating extracellular matrix (ECM) homeostasis, cell signaling, and apoptosis. HTRA1 degrades various ECM components, including fibronectin and proteoglycans, and modulates transforming growth factor-beta (TGF-β) signaling by cleaving its binding proteins. Dysregulation of HTRA1 is linked to age-related diseases, particularly age-related macular degeneration (AMD), where its overexpression disrupts retinal pigment epithelium function. It also plays roles in cancer progression, osteoarthritis, and neurodegenerative disorders.

HTRA1 antibodies are widely utilized in research to detect protein expression via Western blot, immunohistochemistry, or ELISA. They help elucidate HTRA1's pathological mechanisms, such as its dual role in suppressing or promoting tumors depending on context. In AMD, HTRA1 antibodies aid in identifying disease biomarkers and evaluating therapeutic targets. Recent studies explore neutralizing HTRA1 antibodies or inhibitors to mitigate ECM degradation in AMD and fibrosis-related conditions.

Despite its significance, HTRA1's pleiotropic functions necessitate careful interpretation of experimental results. Ongoing research aims to clarify its tissue-specific roles and therapeutic potential, making HTRA1 antibodies critical for advancing molecular and clinical insights.

       
HTRA1 抗体;HTRA1 ;HTRA1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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