PIWIL3抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04605(PIWIL1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04605(PIWIL1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The PIWIL3 antibody is a research tool designed to detect and study the PIWI-like protein 3 (PIWIL3/HIWI3), a member of the PIWI/Argonaute protein family. PIWI proteins are primarily associated with germline development, stem cell maintenance, and RNA silencing through interactions with piwi-interacting RNAs (piRNAs). PIWIL3. though less characterized than other PIWI members (e.g., PIWIL1/HIWI, PIWIL2/HILI), is implicated in regulating transposon silencing, epigenetic modifications, and post-transcriptional gene expression, particularly in reproductive tissues. Its expression is often restricted to the testes under normal physiological conditions but has been observed in certain cancers, including testicular, ovarian, and hepatocellular carcinomas, suggesting potential roles in tumorigenesis or cancer stem cell regulation.

Antibodies targeting PIWIL3 enable researchers to investigate its localization (cytoplasmic/nuclear), expression patterns, and interactions via techniques like Western blotting, immunohistochemistry, or immunofluorescence. These studies help elucidate PIWIL3’s biological functions, such as its involvement in piRNA pathways or aberrant activation in malignancies. However, challenges remain, including cross-reactivity with other PIWI proteins and limited commercial availability of validated antibodies. Current research focuses on clarifying PIWIL3’s dual roles in gametogenesis and cancer progression, positioning it as a potential biomarker or therapeutic target in reproductive disorders or oncotherapy.