INTS1抗体

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P04602(INTS1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

**Background of INTS1 Antibody**

The INTS1 (Integrator Complex Subunit 1) antibody is a tool used to study the INTS1 protein, a critical component of the Integrator complex. This large, multi-subunit complex is evolutionarily conserved and plays diverse roles in RNA processing, transcription regulation, and genomic stability. The Integrator complex is primarily associated with RNA polymerase II (RNA Pol II), where it participates in the 3' end processing of small nuclear RNAs (snRNAs) and transcription termination of certain messenger RNAs (mRNAs). INTS1. as a core subunit, is essential for the structural integrity and catalytic activity of the complex.

Studies have linked INTS1 to transcriptional pausing, promoter-proximal termination, and enhancer RNA biogenesis, highlighting its regulatory influence on gene expression. Dysregulation of INTS1 or the Integrator complex has been implicated in developmental disorders, cancer, and neurological diseases. For example, INTS1 mutations are associated with neurodevelopmental abnormalities, while altered expression is observed in tumors, suggesting roles in cell proliferation and differentiation.

The INTS1 antibody enables researchers to investigate these mechanisms through techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in characterizing protein expression patterns, subcellular localization, and interactions within the Integrator complex. Such research enhances understanding of transcriptional regulation and may identify therapeutic targets for diseases linked to Integrator dysfunction.