ARHGAP4抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: K562 cell, Primary antibody: P04595(ARHGAP4 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04595(ARHGAP4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P04595(ARHGAP4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The ARHGAP4 antibody is a research tool designed to detect and study the ARHGAP4 protein, a member of the Rho GTPase-activating protein (RhoGAP) family. ARHGAP4 regulates Rho GTPases, such as RhoA, Cdc42. and Rac1. by accelerating their hydrolysis of GTP to GDP, thereby inactivating these signaling molecules. Rho GTPases are critical for cytoskeletal reorganization, cell migration, and intracellular signaling, making ARHGAP4 a key player in processes like immune cell function, cancer metastasis, and neuronal development.

ARHGAP4 is highly expressed in hematopoietic cells and has been implicated in leukemogenesis and immune regulation. Studies suggest its role in T-cell activation, apoptosis, and chemotaxis. In cancer, dysregulated ARHGAP4 expression may contribute to tumor progression by modulating cell adhesion and motility. The antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ARHGAP4’s expression patterns, subcellular localization, and interactions in normal and diseased tissues.

Researchers utilize ARHGAP4 antibodies to explore its involvement in pathological conditions, including hematologic malignancies and autoimmune disorders. Recent work also highlights its potential as a therapeutic target, particularly in cancers with aberrant Rho pathway activity. Validation of antibody specificity through knockdown/knockout experiments ensures reliable detection, aiding mechanistic studies of ARHGAP4’s regulatory networks. This tool remains vital for unraveling the protein’s biological and clinical significance.