ATP1A1抗体

The ATP1A1 antibody targets the alpha-1 subunit of the Na+/K+ ATPase, a critical enzyme responsible for maintaining electrochemical gradients across cell membranes by actively transporting sodium and potassium ions. This transmembrane protein, encoded by the ATP1A1 gene, is essential for cellular homeostasis, regulating processes like osmotic balance, neuronal excitability, and secondary transport of nutrients. ATP1A1 is ubiquitously expressed, with high abundance in tissues such as the kidney, brain, and heart. Antibodies against ATP1A1 are widely used in research to investigate its expression, localization, and function in physiological and pathological contexts. Dysregulation of Na+/K+ ATPase activity has been implicated in diseases including hypertension, neurological disorders, and cancer, where altered ATP1A1 expression may correlate with tumor progression or drug resistance. In autoimmune research, ATP1A1 autoantibodies have been associated with conditions like rheumatoid arthritis and neurodegenerative diseases, suggesting a role in immune-mediated pathogenesis. These antibodies are also utilized in diagnostic assays and mechanistic studies to explore ion transport defects or evaluate therapeutic interventions targeting pump activity. Their applications span Western blotting, immunohistochemistry, and flow cytometry, enabling precise analysis of ATP1A1 in diverse experimental models.