ABCA2抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04525(ABCA2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04525(ABCA2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The ABCA2 antibody is a research tool designed to detect and study the ATP-binding cassette subfamily A member 2 (ABCA2) protein, a transmembrane transporter belonging to the ABC superfamily. ABCA2 is primarily expressed in the central nervous system, particularly in oligodendrocytes, and plays roles in lipid metabolism, intracellular trafficking, and lysosomal function. It is implicated in myelination processes and neuronal homeostasis, with studies suggesting its involvement in cholesterol transport and sphingolipid distribution.

ABCA2 has garnered attention due to its potential links to neurological disorders, including Alzheimer's disease, and certain cancers. Mutations or dysregulation of ABCA2 may contribute to pathological lipid accumulation or drug resistance in cancer cells. The ABCA2 antibody enables researchers to investigate its expression patterns, subcellular localization (e.g., endosomal/lysosomal compartments), and interactions with other molecules through techniques like Western blotting, immunohistochemistry, and immunofluorescence.

Recent studies also explore ABCA2's role in modulating responses to chemotherapeutic agents, highlighting its relevance in oncology. However, its precise molecular mechanisms remain partially unresolved. The development and validation of specific ABCA2 antibodies continue to support efforts to clarify its physiological functions and therapeutic potential in disease contexts.