S1PR4抗体

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     Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: Rat kidney tissue, Primary antibody: P04512(S1PR4 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04512(S1PR4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

S1PR4 (sphingosine-1-phosphate receptor 4) is a G protein-coupled receptor that binds sphingosine-1-phosphate (S1P), a bioactive lipid mediator regulating immune cell trafficking, vascular function, and inflammatory responses. It belongs to the S1PR family (S1PR1-S1PR5), with S1PR4 being selectively expressed in immune cells, particularly lymphocytes, dendritic cells, macrophages, and natural killer (NK) cells. Unlike other S1PRs, S1PR4 couples primarily to Gα12/13 and Gαi proteins, modulating cell migration, adhesion, and cytokine secretion. Its signaling influences immune cell homing, particularly in lymphoid and peripheral tissues, and plays a role in inflammatory and autoimmune conditions.

Research highlights S1PR4's involvement in diseases like cancer, sepsis, and rheumatoid arthritis. In tumors, S1PR4 may promote immunosuppressive microenvironments by regulating myeloid cell activity. Studies using S1PR4-knockout models suggest its role in dampening excessive inflammation, linking it to sepsis pathology. S1PR4 antibodies are critical tools for detecting receptor expression, blocking S1P interactions, or modulating downstream signaling in experimental settings. Therapeutic strategies targeting S1PR4. including monoclonal antibodies, are under exploration to fine-tune immune responses without systemic immunosuppression. However, its functional overlap with other S1PRs and tissue-specific roles remain areas of active investigation, necessitating precise antibody validation for research and clinical applications.