S1PR3抗体

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     Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: PC3 cells, Primary antibody: P04511(S1PR3 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

The S1PR3 antibody targets the sphingosine-1-phosphate receptor 3 (S1PR3), a G protein-coupled receptor that binds the bioactive lipid sphingosine-1-phosphate (S1P). S1PR3 is one of five S1P receptor subtypes (S1PR1-5) and plays a critical role in regulating cellular processes such as cell migration, proliferation, and survival. It is widely expressed in various tissues, including the immune, cardiovascular, and nervous systems, and is implicated in inflammation, angiogenesis, and cancer progression.

S1PR3-specific antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in both physiological and pathological contexts. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect S1PR3 in cell lines, tissues, or animal models. Researchers also employ these antibodies to explore S1PR3's role in diseases, such as cancer metastasis, autoimmune disorders, and vascular dysfunction.

The development and validation of S1PR3 antibodies require stringent specificity testing, often using knockout models or competitive binding assays, to ensure minimal cross-reactivity with other S1P receptors. Recent studies highlight S1PR3's potential as a therapeutic target, with antibodies being investigated for their ability to block S1P-mediated pathways in preclinical models. Understanding S1PR3 dynamics through antibody-based research continues to advance insights into its therapeutic applications and biomarker potential.