TRPM5抗体

+ +

•  

   

     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: P04505(TRPM5 Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04505(TRPM5 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04505(TRPM5 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

TRPM5 (Transient Receptor Potential Cation Channel Subfamily M Member 5) is a calcium-activated, non-selective cation channel critical in mediating sensory signaling, particularly in taste transduction. It is predominantly expressed in taste receptor cells, where it couples G protein-coupled receptor (GPCR) activation to membrane depolarization, enabling signal transmission for sweet, bitter, and umami tastes. TRPM5 is also found in other tissues, including the gut, respiratory epithelium, and pancreatic β-cells, implicating roles in metabolic regulation and chemosensation.

TRPM5 antibodies are essential tools for studying its expression, localization, and function. These antibodies typically target specific epitopes, such as intracellular N- or C-terminal domains, and are validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers use TRPM5 antibodies to investigate its involvement in diseases like obesity, diabetes, and respiratory disorders, as TRPM5 knockout models show altered glucose homeostasis and taste perception. Additionally, TRPM5's temperature and voltage sensitivity make it a focus in neurobiology and pharmacology studies. Reliable antibodies help elucidate its modulation by signaling molecules (e.g., PLC pathways) and potential as a therapeutic target. Validation via knockout controls or peptide blocking ensures specificity, which is crucial given structural similarities within the TRP channel family.