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  • S100A4抗体
  • S100A4抗体

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S100A4抗体

Rabbit Polyclonal S100A4 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
S100A4抗体
英文名称：
Rabbit Polyclonal S100A4 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 208 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
S100A4

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

Aliases42A, 18A2, CAPL, FSP1, MTS1, P9KA, PEL98
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human S100A4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04437(S100A4 Antibody) at dilution 1/80. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04437(S100A4 Antibody) at dilution 1/80. (Original magnification: ×200)    


           

参考文献

以下是关于S100A4抗体的3篇参考文献示例(均为虚构，仅供参考格式)：

1. **文献名称**: *"Monoclonal antibody targeting S100A4 inhibits metastatic growth in murine models"*

**作者**: Schneider M, et al.

**摘要**: 该研究开发了一种针对S100A4蛋白的单克隆抗体，证明其在乳腺癌小鼠模型中能显著抑制肿瘤细胞迁移和肺转移，机制可能与阻断S100A4-RAGE信号通路相关。

2. **文献名称**: *"S100A4 as a prognostic biomarker: Validation of a novel antibody-based assay in colorectal cancer"*

**作者**: Bresnick AR, et al.

**摘要**: 研究者通过高特异性S100A4抗体建立免疫组化检测方法，发现S100A4在结直肠癌组织中的高表达与患者预后不良及转移风险增加显著相关。

3. **文献名称**: *"Therapeutic potential of anti-S100A4 antibody in pulmonary fibrosis"*

**作者**: Garrett SC, et al.

**摘要**: 利用人源化S100A4抗体干预肺纤维化小鼠模型，结果显示其通过抑制成纤维细胞活化和胶原沉积减轻纤维化进展，提示其在纤维化疾病中的治疗潜力。

(注：以上文献为示例，实际引用需检索真实数据库如PubMed并核实信息。)

       

背景信息

S100A4. also known as calvascularin, metastasin, or FSP1 (fibroblast-specific protein 1), is a calcium-binding protein belonging to the S100 family. It plays critical roles in regulating cellular processes such as matrix remodeling, cell motility, and epithelial-mesenchymal transition (EMT). S100A4 is closely associated with cancer progression, particularly metastasis, and is implicated in fibrotic diseases and inflammatory conditions. Its expression is often upregulated in aggressive tumors and stromal fibroblasts, making it a biomarker for poor prognosis in cancers like breast, colorectal, and pancreatic.

S100A4 antibodies are essential tools for detecting and quantifying S100A4 protein levels in research and diagnostics. These antibodies enable the study of S100A4's localization, interactions, and functional roles via techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence. Monoclonal antibodies (e.g., clone D9F9) offer high specificity, while polyclonal antibodies may detect multiple epitopes, enhancing sensitivity. Validated antibodies are critical for ensuring reproducibility in studies exploring S100A4's involvement in tumor microenvironment modulation, fibroblast activation, or inflammatory signaling.

Recent research highlights S100A4's potential as a therapeutic target. Antibodies blocking S100A4 activity or neutralizing its extracellular functions are under investigation for anti-metastatic or anti-fibrotic therapies. However, challenges remain in understanding its dual intracellular/extracellular roles and cell-type-specific effects. Reliable S100A4 antibodies thus remain vital for advancing both basic research and clinical applications.

       
S100A4抗体;S100A4;S100A4 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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