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  • RRAD抗体

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RRAD抗体

Rabbit Polyclonal RRAD Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
RRAD抗体
英文名称：
Rabbit Polyclonal RRAD Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 207 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
RRAD

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesT-cell receptor beta chain V region CTL-L17, TCRB
WB Predicted band size13.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TCRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the Central region of human TCRB.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       All lanes : Anti-TCRB Antibody (Center)(P32986) at 1:1000 dilution Lane 1: Jurkat whole cell lysates Lane 2: MOLT-4 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG,  (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 15 kDa Blocking/Dilution buffer: 5% NFDM/TBST.    


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       Anti-TCRB Antibody (Center)(P32986) at 1:500 dilution + MDA-MB-231 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG,  (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size :  15 kDa Blocking/Dilution buffer: 5% NFDM/TBST.    


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       Anti-TCRB Antibody (Center) at 1:1000 dilution + human spleen lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG,  (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size :15 kDa Blocking/Dilution buffer: 5% NFDM/TBST.    


           

参考文献

以下是关于RRAD抗体的参考文献示例(注：以下为模拟虚构内容，实际文献需通过学术数据库检索验证)：

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1. **文献名称**: *"RRAD as a Biomarker in Type 2 Diabetes: Role in Insulin Resistance"*

**作者**: Moyers JS, et al.

**摘要**: 研究通过免疫印迹(Western blot)和免疫组化(IHC)分析RRAD蛋白在糖尿病模型中的表达，发现RRAD在胰岛素抵抗组织中显著上调，提示其可能通过干扰胰岛素信号通路参与糖尿病病理机制。

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2. **文献名称**: *"RRAD Promotes Lung Cancer Metastasis via GTPase Signaling Pathways"*

**作者**: Wang Y, et al.

**摘要**: 利用RRAD特异性抗体检测肺癌细胞中RRAD的定位与表达，证实RRAD通过激活Rho-GTPase通路增强肿瘤细胞迁移和侵袭能力，为癌症治疗提供潜在靶点。

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3. **文献名称**: *"Interaction of RRAD with Calcineurin: Implications for Cellular Motility"*

**作者**: Reynet C, Kahn CR

**摘要**: 研究采用免疫共沉淀(Co-IP)和免疫荧光技术，揭示RRAD与钙调神经磷酸酶(calcineurin)的相互作用，调控细胞骨架重组和迁移功能，为RRAD在非代谢疾病中的作用提供证据。

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4. **文献名称**: *"Multifaceted Roles of RRAD: From Diabetes to Cancer"* (综述)

**作者**: Zhang L, et al.

**摘要**: 综述总结了RRAD在不同疾病中的分子机制，强调抗体技术在RRAD蛋白检测中的应用(如ELISA、流式细胞术)，并讨论其作为治疗靶点的潜力。

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**建议**：通过PubMed、Web of Science或Google Scholar检索真实文献时，可使用关键词“RRAD antibody”、“RRAD GTPase”或“RRAD in disease”。

       

背景信息

RRAD (Ras-related associated with diabetes) is a small GTP-binding protein encoded by the *RRAD* gene, initially identified for its role in insulin resistance and type 2 diabetes. It regulates glucose uptake by interfering with insulin signaling pathways, particularly through interactions with key components like the insulin receptor and Akt. Beyond metabolic disorders, RRAD overexpression has been linked to cancers, including lung and breast cancer, where it promotes tumor progression via pathways like MAPK/ERK.

RRAD antibodies are tools used to detect and study RRAD protein expression in research and diagnostics. They aid in elucidating its cellular localization, interaction partners, and disease-related mechanisms. In autoimmune contexts, anti-RRAD antibodies have been explored as potential biomarkers, though their clinical relevance remains under investigation. Commercial RRAD antibodies are typically developed in rabbit or mouse hosts, targeting specific epitopes for applications in Western blot, immunohistochemistry, or immunofluorescence.

Recent studies highlight RRAD's dual role in metabolism and oncology, driving interest in therapeutic targeting. However, antibody specificity and validation challenges persist, emphasizing the need for rigorous testing in diverse biological models. Overall, RRAD antibodies remain critical for advancing understanding of its pathophysiological roles.

       
RRAD抗体;RRAD;RRAD Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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