PAK3抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P04410(PAK3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P04410(PAK3 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04410(PAK3 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The PAK3 antibody is a crucial tool for studying the p21-activated kinase 3 (PAK3), a serine/threonine kinase belonging to the PAK family, which plays pivotal roles in cytoskeletal dynamics, cell signaling, and neuronal development. PAK3 is activated by binding to Rho-family GTPases like Cdc42 and Rac, regulating processes such as cell motility, apoptosis, and synaptic plasticity. It is highly expressed in the brain, where it contributes to dendritic spine formation, neuronal connectivity, and cognitive function. Mutations or dysregulation of PAK3 are linked to neurodevelopmental disorders, including X-linked intellectual disability and autism spectrum disorders, as well as cancer progression.

PAK3 antibodies are designed to detect specific epitopes of the PAK3 protein, enabling researchers to investigate its expression, localization, and post-translational modifications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Given the structural homology among PAK family members (PAK1-6), high specificity is critical to avoid cross-reactivity. Many PAK3 antibodies target unique regions, such as the kinase domain or regulatory motifs, to distinguish PAK3 from other isoforms.

Research utilizing PAK3 antibodies has advanced understanding of its role in diseases and potential therapeutic targeting. For example, studies reveal PAK3's involvement in β-amyloid toxicity in Alzheimer’s models and its oncogenic signaling in breast and gastric cancers. Validating antibody specificity through knockout controls or siRNA remains essential for reliable data interpretation. Overall, PAK3 antibodies are indispensable for unraveling the kinase's multifaceted functions in health and disease.