NFATC2抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: P04375(NFATC2 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    

  
  

**Background of NFATC2 Antibody**

NFATC2 (Nuclear Factor of Activated T Cells 2) is a member of the NFAT transcription factor family, which plays critical roles in immune response, cell differentiation, and development. NFATC2 is regulated by calcium-dependent calcineurin signaling. Upon activation, it translocates from the cytoplasm to the nucleus, where it binds to DNA and regulates genes involved in T-cell activation, cytokine production, and osteoclastogenesis. Dysregulation of NFATC2 is linked to autoimmune diseases, cancer progression, and bone disorders.

NFATC2 antibodies are essential tools for studying its expression, localization, and function. These antibodies target specific epitopes within the protein, enabling detection via techniques like Western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Researchers use NFATC2 antibodies to investigate its role in immune modulation, tumor microenvironment interactions, and therapeutic targeting. For example, in cancer biology, NFATC2 may act as both an oncogene and tumor suppressor, depending on cellular context.

High-quality NFATC2 antibodies exhibit specificity validated by knockout controls or siRNA knockdown. Commercial antibodies often include datasheets detailing applications, species reactivity (e.g., human, mouse, rat), and recommended experimental conditions. Understanding NFATC2's dual roles in health and disease highlights the importance of reliable antibodies in dissecting its complex regulatory networks and translational potential.