CD163 抗体

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P04339(CD163  Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P04339(CD163  Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

CD163. a member of the scavenger receptor cysteine-rich (SRCR) superfamily, is a transmembrane glycoprotein predominantly expressed on monocytes and tissue-resident macrophages. It contains nine extracellular SRCR domains, which mediate its interaction with hemoglobin-haptoglobin (Hb-Hp) complexes during erythrophagocytosis. CD163 plays a critical role in anti-inflammatory processes by facilitating the clearance of free hemoglobin, thereby mitigating oxidative tissue damage. Its expression is tightly regulated by inflammatory stimuli: pro-inflammatory cytokines (e.g., TNF-α) downregulate it, while anti-inflammatory mediators (e.g., glucocorticoids or IL-10) upregulate it.

As a marker of M2-polarized macrophages, CD163 is implicated in tissue repair, immune regulation, and resolution of inflammation. Its soluble form (sCD163), shed by ADAM17-mediated cleavage, serves as a biomarker for macrophage activation in conditions like sepsis, atherosclerosis, and chronic liver disease. CD163 antibodies are essential tools in research and diagnostics, enabling the identification of macrophage subsets in immunohistochemistry, flow cytometry, and Western blotting. They also aid in studying CD163's role in diseases such as cancer, where tumor-associated macrophages overexpressing CD163 correlate with immunosuppression and poor prognosis.

Antibodies targeting specific epitopes or isoforms help elucidate CD163’s functional diversity across tissues and pathological contexts, underscoring its therapeutic and diagnostic potential.