ANP32C抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04326(ANP32C Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P04326(ANP32C Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of ANP32C Antibody**

ANP32C (Acidic Nuclear Phosphoprotein 32 Family Member C) belongs to the ANP32 family, a group of evolutionarily conserved proteins involved in diverse cellular processes, including chromatin remodeling, RNA transport, and apoptosis. While ANP32A and ANP32B are well-studied, ANP32C remains less characterized, though it shares structural features such as an N-terminal leucine-rich repeat (LRR) domain and a C-terminal acidic tail. These domains suggest roles in protein-protein interactions and modulation of transcriptional regulation.

ANP32C antibodies are critical tools for investigating the protein’s expression, localization, and molecular functions. Studies indicate ANP32C may interact with transcription factors, histone chaperones, or viral components, potentially influencing pathways linked to cancer progression or neurodegenerative disorders. For example, ANP32 proteins are implicated in regulating the PP2A phosphatase complex, which is often dysregulated in diseases like leukemia.

Research using ANP32C antibodies has helped uncover its tissue-specific expression patterns and potential redundancy with other ANP32 members. Challenges include ensuring antibody specificity due to high sequence homology within the family. Nonetheless, these antibodies enable applications such as Western blotting, immunofluorescence, and co-immunoprecipitation, advancing insights into ANP32C’s role in cellular homeostasis and disease mechanisms. Continued development of selective ANP32C antibodies is vital for dissecting its unique biological contributions.