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MAGEA3抗体

Rabbit Polyclonal MAGEA3 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-09

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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产品详情:

中文名称：
MAGEA3抗体
英文名称：
Rabbit Polyclonal MAGEA3 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 162 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
MAGEA3

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesHIP8; HYPD; CT1.3; MAGE3; MAGEA6
WB Predicted band size35 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human MAGEA3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human testis tissue, A549 cells, PC3 cells, Primary antibody: P04318(MAGEA3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P04318(MAGEA3 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04318(MAGEA3 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于MAGEA3抗体的3篇参考文献及其摘要概括：

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1. **文献名称**：*"MAGE-A3 is a frequent tumor antigen in metastatic colorectal cancer recognized by CD4+ T cells"*

**作者**：Atanackovic D. et al.

**摘要**：该研究探讨了MAGEA3在转移性结直肠癌患者中的免疫原性，发现患者体内存在针对MAGEA3的CD4+ T细胞及体液免疫反应，提示其作为肿瘤疫苗或免疫治疗靶点的潜力。

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2. **文献名称**：*"Development of a human single-chain variable fragment antibody against MAGE-A3"*

**作者**：Tiwari R. et al.

**摘要**：研究团队开发了一种针对MAGEA3的人源化单链抗体(scFv)，通过噬菌体展示技术筛选并验证其特异性结合能力，为靶向MAGEA3的肿瘤免疫治疗(如CAR-T或抗体药物偶联物)提供了工具。

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3. **文献名称**：*"Antibody responses to cancer/testis antigens in melanoma patients: Association with clinical features and NY-ESO-1 expression"*

**作者**：Gure A.O. et al.

**摘要**：该研究分析了黑色素瘤患者对多种癌症睾丸抗原(包括MAGEA3)的抗体反应，发现MAGEA3抗体水平与肿瘤进展和NY-ESO-1表达相关，提示其作为预后标志物的可能性。

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**补充说明**：MAGEA3作为癌症睾丸抗原，其抗体研究多集中于诊断标志物开发、免疫治疗靶点探索(如疫苗或工程化T细胞)以及患者预后评估。如需具体实验细节或更多文献，建议通过PubMed或SciHub检索关键词“MAGEA3 antibody”或“MAGEA3 immunotherapy”。

       

背景信息

The MAGE-A3 antibody targets the melanoma-associated antigen A3 (MAGEA3), a member of the cancer-testis antigen (CTA) family. CTAs like MAGEA3 are normally expressed in immune-privileged germline tissues (e.g., testes, placenta) but are aberrantly reactivated in various cancers, including melanoma, lung, and head/neck carcinomas. This restricted expression pattern makes MAGEA3 a promising target for cancer immunotherapy and a potential biomarker for tumor detection.

MAGEA3 antibodies are widely used in research to study its role in oncogenesis, including promoting tumor cell proliferation, metastasis, and resistance to apoptosis. These antibodies enable detection of MAGEA3 protein via techniques like immunohistochemistry (IHC), Western blot, or flow cytometry, aiding in cancer diagnosis and prognosis. Clinically, MAGEA3 has been explored in vaccine-based therapies and adoptive T-cell therapies, though clinical trials have shown mixed results, possibly due to tumor heterogeneity and immune evasion mechanisms.

Despite challenges, MAGEA3 remains a focus due to its tumor-specificity and potential for minimizing off-target toxicity. Research continues to optimize antibody-based strategies, including CAR-T cells and bispecific antibodies, to enhance targeting efficacy. However, variability in MAGEA3 expression across patients and cancers underscores the need for companion diagnostics to identify suitable candidates for MAGEA3-directed therapies.

       
MAGEA3抗体;MAGEA3;MAGEA3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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