Rabbit Polyclonal SMURF1 Antibody

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04304(SMURF1 Antibody) at dilution 1/15. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04304(SMURF1 Antibody) at dilution 1/15. (Original magnification: ×200)    

  
  

**Background of SMURF1 Antibody**

SMURF1 (SMAD Ubiquitination Regulatory Factor 1) is an E3 ubiquitin ligase belonging to the HECT (homologous to E6-AP C-terminus) family. It plays a critical role in regulating protein degradation and localization via the ubiquitin-proteasome system, primarily targeting substrates involved in cell differentiation, apoptosis, and migration. SMURF1 is best known for its interaction with TGF-β/BMP signaling pathways, where it promotes the ubiquitination and degradation of SMAD proteins and receptors, thereby modulating cellular responses to these growth factors. Dysregulation of SMURF1 has been implicated in various pathologies, including cancer progression, fibrosis, and bone disorders.

Antibodies against SMURF1 are widely used in research to study its expression, localization, and functional mechanisms. These antibodies enable detection of SMURF1 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Specific clones or polyclonal preparations may vary in their binding affinity and specificity, requiring validation for experimental contexts. Studies using SMURF1 antibodies have revealed its role in processes such as embryonic development, tissue homeostasis, and disease pathogenesis, making it a key target for therapeutic exploration. Reliable SMURF1 antibodies are essential for elucidating its complex regulatory networks and potential clinical applications.