Rabbit Polyclonal LIN28A Antibody

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P04297(LIN28A Antibody) at dilution 1/15. (Original magnification: ×200)    

  
  

LIN28A is a conserved RNA-binding protein that plays critical roles in embryonic development, pluripotency, and metabolism. It functions by regulating gene expression at post-transcriptional levels, primarily through binding to mRNAs and small RNAs like let-7 microRNAs to inhibit their maturation. LIN28A is highly expressed in embryonic stem cells and primordial germ cells but is typically downregulated in most somatic tissues. Its dysregulation has been linked to various cancers, developmental disorders, and metabolic diseases, making it a biomarker and therapeutic target in oncology research.

LIN28A antibodies are essential tools for detecting and quantifying this protein in experimental settings. They are widely used in techniques such as Western blotting, immunofluorescence, immunohistochemistry, and flow cytometry to study LIN28A's expression patterns, subcellular localization, and interaction partners. These antibodies are critical for investigating LIN28A's role in maintaining stem cell pluripotency, reprogramming somatic cells, and driving tumorigenesis. Most commercially available LIN28A antibodies are raised against specific epitopes, often within its cold-shock domain or zinc-knuckle motifs, which are crucial for its RNA-binding activity.

Validation of LIN28A antibody specificity is vital, as homologous proteins like LIN28B may cross-react. Researchers rely on these antibodies to explore LIN28A's therapeutic potential in tissue regeneration and cancer treatment while deciphering its complex regulatory networks in development and disease.