Rabbit Polyclonal AFF2 Antibody

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal lung tissue, Primary antibody: P04262(AFF2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04262(AFF2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04262(AFF2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The AFF2 antibody is a research tool targeting the AFF2 protein (AF4/FMR2 family member 2), also known as FMR2. AFF2 is a member of the AFF family of nuclear transcriptional regulators, which play roles in transcriptional elongation, chromatin remodeling, and RNA-binding processes. The AFF2 gene is located on the X chromosome (Xq28) and is associated with neurodevelopmental disorders. Mutations or epigenetic silencing of AFF2 are linked to FRAXE intellectual disability, a rare X-linked syndrome characterized by cognitive impairment, behavioral challenges, and speech delays. FRAXE is distinct from Fragile X syndrome (FMR1-related) but shares overlapping clinical features.

AFF2 antibodies are primarily used in biomedical research to study protein expression, localization, and function in cellular and disease models. They enable detection of AFF2 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using these antibodies have helped elucidate AFF2's role in neuronal development, synaptic plasticity, and its interaction with other transcriptional regulators. Despite progress, AFF2's precise molecular mechanisms remain incompletely understood, and the antibody serves as a critical reagent for ongoing investigations into neurodevelopmental disorders and potential therapeutic targets. Commercial AFF2 antibodies are typically validated in knockout controls to ensure specificity.