Rabbit Polyclonal ADAMTS2 Antibody

The ADAMTS2 antibody is a tool used to detect and study ADAMTS2. a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family of extracellular proteases. ADAMTS2 plays a critical role in collagen processing by cleaving the N-terminal propeptides of procollagen types I, II, and V, a step essential for proper fibrillogenesis and collagen cross-linking. Mutations in the ADAMTS2 gene are linked to Ehlers-Danlos syndrome (dermatosparaxis type), a rare connective tissue disorder characterized by fragile skin, joint hypermobility, and delayed wound healing. Researchers use ADAMTS2 antibodies in techniques like Western blotting, immunohistochemistry, or immunofluorescence to investigate its expression, localization, and function in tissues such as skin, bone, and blood vessels. These studies help elucidate its involvement in tissue development, fibrosis, cancer metastasis, or cardiovascular diseases, where collagen remodeling is pivotal. ADAMTS2 antibodies may also aid in modeling connective tissue disorders or validating therapeutic targets. Commercial antibodies are typically raised against specific epitopes (human, mouse, or rat), with monoclonal variants offering high specificity and polyclonal ones detecting multiple epitopes. Proper validation ensures minimal cross-reactivity with other ADAMTS family members. Overall, ADAMTS2 antibodies are vital for advancing research on extracellular matrix biology and related pathologies.