Rabbit Polyclonal ABCG5 Antibody

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04248(ABCG5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

ABCG5 antibodies are essential tools for studying the ATP-binding cassette subfamily G member 5 (ABCG5), a transmembrane protein critical for sterol homeostasis. ABCG5 forms a heterodimer with ABCG8. functioning as a cholesterol efflux transporter in the liver and intestine. This complex mediates the excretion of dietary sterols, including cholesterol and plant sterols, into bile and limits their absorption in the gut. Mutations in the ABCG5 gene are linked to sitosterolemia, a rare autosomal recessive disorder characterized by excessive accumulation of plant sterols in plasma and tissues, leading to cardiovascular and hematologic complications.

Researchers employ ABCG5 antibodies in various applications, such as Western blotting, immunohistochemistry, and immunofluorescence, to detect protein expression, localization, and regulation in tissues like the liver, intestine, and gallbladder. These antibodies aid in exploring ABCG5's role in lipid metabolism, drug resistance, and diseases like atherosclerosis or gallstone formation. Additionally, they are valuable in preclinical studies to evaluate therapeutic interventions targeting sterol transport pathways. High-specificity ABCG5 antibodies are crucial for distinguishing ABCG5 from related ABC transporters, ensuring accurate experimental outcomes. Their development and validation continue to support advancements in understanding sterol-related pathologies and potential treatments.