Rabbit Polyclonal ABCG1 Antibody

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: HT29 cells, Primary antibody: P04247(ABCG1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P04247(ABCG1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ABCG1 antibody is a crucial tool in studying the ATP-binding cassette (ABC) transporter family, specifically targeting the ABCG1 protein, which plays a vital role in cellular lipid homeostasis. ABCG1. a member of the ABCG subfamily, functions as a transmembrane transporter facilitating cholesterol and phospholipid efflux from cells, particularly macrophages, to high-density lipoprotein (HDL). This process is essential for preventing intracellular lipid accumulation, a key factor in atherosclerosis and metabolic disorders. Structurally, ABCG1 forms a heterodimer and operates as a "half-transporter," requiring dimerization for functionality. Its expression is regulated by liver X receptors (LXRs), linking it to lipid metabolism and inflammation pathways.

ABCG1 antibodies are widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, and flow cytometry. They help elucidate ABCG1's role in diseases such as cardiovascular disease, diabetes, and cancer, where dysregulated lipid metabolism contributes to pathogenesis. Polyclonal and monoclonal variants target specific epitopes (e.g., C-terminal regions), enabling precise localization and functional studies. Recent studies also explore ABCG1's involvement in immune regulation and drug resistance, highlighting its therapeutic potential. However, challenges remain in standardizing antibody specificity across experimental models, necessitating rigorous validation. Overall, ABCG1 antibodies are indispensable for advancing understanding of lipid transport mechanisms and their disease implications.