Rabbit Polyclonal ABCC12 Antibody

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04244(ABCC12 Antibody) at dilution 1/10. (Original magnification: ×200)    

  
  

The ABCC12 antibody is designed to detect the ATP-binding cassette subfamily C member 12 (ABCC12), a transmembrane protein belonging to the ABC transporter superfamily. These transporters utilize ATP hydrolysis to shuttle various substrates, including lipids, ions, and xenobiotics, across cellular membranes. ABCC12. also known as multidrug resistance-associated protein 9 (MRP9), is encoded by the *ABCC12* gene located on chromosome 16q12.1. Though its precise physiological role remains under investigation, ABCC12 is hypothesized to participate in efflux transport of endogenous or exogenous compounds, potentially influencing drug resistance in cancers. It is expressed in tissues like the liver, kidneys, testes, and mammary glands.

ABCC12 antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Research links ABCC12 to several pathologies: mutations in the gene are associated with hereditary hearing loss, while overexpression has been implicated in cancer progression and chemoresistance. However, its role in disease mechanisms is not fully elucidated, necessitating further exploration.

Commercial ABCC12 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). Validation includes testing for specificity via knockout controls or siRNA silencing. These antibodies aid in both basic research and potential clinical applications, such as biomarker discovery or therapeutic targeting in multidrug-resistant cancers.