Rabbit Polyclonal ABCC10 Antibody

ABCC10 antibody is a crucial tool in studying the ATP-binding cassette (ABC) transporter family, specifically targeting the ABCC10 protein, also known as multidrug resistance-associated protein 7 (MRP7). ABCC10 is a transmembrane transporter involved in the efflux of various endogenous and exogenous substrates, including chemotherapeutic agents, antiviral drugs, and lipids. Its overexpression is linked to multidrug resistance (MDR) in cancers, limiting treatment efficacy. Researchers use ABCC10 antibodies to detect and quantify protein expression in tissues or cell lines, aiding in understanding its role in drug resistance, cellular detoxification, and disease progression. These antibodies are employed in techniques like Western blotting, immunohistochemistry, and flow cytometry to study ABCC10 localization, regulation, and interactions. Recent studies focus on its potential as a biomarker for cancer prognosis and a therapeutic target to overcome MDR. Commercial ABCC10 antibodies are typically monoclonal or polyclonal, validated for specificity and sensitivity. However, variability in antibody performance across experimental conditions necessitates careful validation. Ongoing research aims to elucidate ABCC10’s broader physiological functions beyond oncology, including lipid metabolism and immune response, highlighting its multifaceted biological significance.