Rabbit Polyclonal TCF7 Antibody

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P04218(TCF7 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P04218(TCF7 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

TCF7 (T-cell factor 7), also known as TCF-1. is a transcription factor encoded by the *TCF7* gene and a key mediator of the Wnt/β-catenin signaling pathway. It belongs to the TCF/LEF (lymphoid enhancer-binding factor) family, which binds to DNA through a high-mobility group (HMG) domain and regulates target gene expression. TCF7 plays a critical role in embryonic development, immune system regulation, and cell fate determination. In the immune context, it is essential for T-cell development and differentiation, particularly in thymocyte maturation and the formation of CD8+ T-cell memory. Dysregulation of TCF7 is implicated in various diseases, including cancers (e.g., colorectal, leukemia) and autoimmune disorders.

TCF7 antibodies are widely used in research to detect and quantify TCF7 protein expression in cells or tissues. They enable studies on its nuclear localization, interaction with β-catenin, and regulatory mechanisms in Wnt-driven processes. Common applications include Western blotting, immunohistochemistry, flow cytometry, and chromatin immunoprecipitation (ChIP). These antibodies help elucidate TCF7's dual role as both an oncogene and tumor suppressor, depending on cellular context and post-translational modifications. Recent interest has focused on its involvement in immune checkpoint regulation and cancer immunotherapy, particularly its association with T-cell exhaustion in tumors. Validated TCF7 antibodies are crucial for advancing research in immunology, oncology, and developmental biology.